Study on clinical significance of changes in blood coagulation function in pregnant women

Objective To study the clinical significance of dynamic changes in blood coagulation function of pregnant women during pregnancy.Methods One hundred and fifty pregnant women admitted in this hospital during 2010 to 2011 were enrolled for this study.Among them,50 with early pregnancy,50 with pregnancy of second trimester and 50 with prenancy of third trimester were allocated in observation group;and 50 normal non-pregnant women at the same period were selected as control group.Blood samples were examined by RT-2204Csemi-automatic four-channel coagulation analyzer for coagulation parameters including prothrombin time(PT),activated partial thromboplastin time(APTT),plasma thrombin time(TT),international normalized ratio(INR) and fibrinogen(FIB) at two different periods of pregnancy in patients for dynamic testing.Results There was no difference at early period of pregnancy between observation group and control group by statistical analysis(P0.05).The difference in coagulation parameters in mid and late stages of pregnancy between observation group and control group was statistically significant(P 0.05).PT,APTT and INR in pregnant women in late pregnancy period were significantly decreased compared with non-pregnant women and their TT and FIB were significantly longer than those of control group,and their amplitude of increment was closely proportional to the approaching of labor.Conclusion The maternal blood coagulation function is keeping a dynamic equilibrium during different stages of gestation,and it is important to monitor the dynamic changes in blood coagulation function in mothers during pregnancy in order to prevent the occurrence of a series of thrombotic complications during pregnancy and DIC after operation.