Expression and significance of CD_(44)v6 in non-small cell lung cancer(NSCLC)specimens

Objective: To study the expression and significance of CD44v6 in non-small cell lung cancer(NSCLC)specimens. Methods: Immunohistochemical method was used to detect the expression of CD_ 44v6 in 101 NSCLC and 20 non-cancerous pulmonary disease tissue. Their relationships between the biological marker and some clinicopathological parameters were analyzed. Results: The positive rate of CD_ 44v6 in NSCLC was much higher than that in the normal lung tissue(P0.01). The expression of CD_ 44v6 was not related to histopathology(P0.05). CD44v6 expression was positively correlated with TNM stage in NSCLC. The expression rate of CD_ 44v6 was associated with lymph nodal metastasis. CD_ 44v6 expression was not related to tumor volume. The positive expression of CD_ 44v6 had a negative relation to survival time after operation(P0.01). Conclusion: The expression of CD_ 44v6 might play an important role in predicting tumor invasion and metastasis of human NSCLC. CD_ 44v6 may serve as a parameter for predicting recurrence, metastasis and prognosis of lung cancinoma.