Clinical Study on the Expression of CD_(44)v6 in Non-small Cell Lung Cancer

Objective To study the expression and clinical significance of CD_ 44v6 in non-small cell lung cancer ( NSCLC ). MethodsImmunohistochemical SABC method was used to detect the expression level of CD_ 44v6 in 65 cases of NSCLC and 20 cases of normal lung tissues. Results The positive rate of CD_ 44v6 expression in NSCLC was 69.2%, and no distinct staining was detected in the normal lung tissues. There was significant difference in CD_ 44v6 expression level between NSCLC and normal lung tissues(P0.05). The positive rates of CD_ 44v6 expression in lung squamous carcinoma and adenocarcinoma were 78.1% and 60.6%, respectively, which were not significantly different(P0.05). The positive rates of CD_ 44v6 expression in the histological grades I+II and III of NSCLC were 63.6% and 75.0%, respectively, with no significant difference(P0.05). The positive rates of CD_ 44v6 expression in the TNM stages I+II and III+IV were 57.1% and 83.3%, respectively, and the difference of which were significant(P0.05). In the NSCLC with and without lymph node metastasis, the positive rates of CD_ 44v6 expression were 78.9% and 55.6%, respectively, with significant difference(P0.05). Conclusion CD_ 44v6 expression was positively related with the development, progression and lymph node metastasis of NSCLC, and may be helpful for evaluating malignant potential and prognosis of NSCLC.