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2001•Ningxia Medical JournalRequires access

Expression of CD_(44)V_6 in Lung Cancer

Lin Xie

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Abstract

Objectives To study the expression of CD 44 V 6 and its significance in non small cell lung carcinoma(NSCLC).Methods The CD 44 V 6 expression in 40 samples of NSCLC and 30 samples of normal lung tissues were studied by immunohistochemical S-P technique.Results It was found that the expression of CD 44 V 6 in NSCLC was significantly higher than those in normal lung tissue (P0.01);the expression of CD 44 V 6 was not correlated with various histologic types and pathologic grades,but it was associated with clinical stages and lymphaden metastasis.Conclusions The results surgest that CD 44 V 6 positive expression is likely to develope lymphatic metastasis and result in poor prognosis in NSCLC.CD 44 V 6 is considered as one of the indicators for evaluating the progression of lung carcinoma.

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What this paper is about

Objectives To study the expression of CD 44 V 6 and its significance in non small cell lung carcinoma(NSCLC).Methods The CD 44 V 6 expression in 40 samples of NSCLC and 30 samples of normal lung tissues were studied by immunohistochemical S-P technique.Results It was found that the expression of CD 44 V 6 in NSCLC was significantly higher than those in normal lung tissue (P0.01);the expression of CD 44 V 6 was not correlated with various histologic types and pathologic grades,but it was associated with clinical stages and lymphaden metastasis.Conclusions The results surgest that CD 44 V 6 positive expression is likely to develope lymphatic metastasis and result in poor prognosis in NSCLC.CD 44 V 6 is considered as one of the indicators for evaluating the progression of lung carcinoma.

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Available abstract

Objectives To study the expression of CD 44 V 6 and its significance in non small cell lung carcinoma(NSCLC).Methods The CD 44 V 6 expression in 40 samples of NSCLC and 30 samples of normal lung tissues were studied by immunohistochemical S-P technique.Results It was found that the expression of CD 44 V 6 in NSCLC was significantly higher than those in normal lung tissue (P0.01);the expression of CD 44 V 6 was not correlated with various histologic types and pathologic grades,but it was associated with clinical stages and lymphaden metastasis.Conclusions The results surgest that CD 44 V 6 positive expression is likely to develope lymphatic metastasis and result in poor prognosis in NSCLC.CD 44 V 6 is considered as one of the indicators for evaluating the progression of lung carcinoma.

Key concepts: Medicine, Lung cancer, Immunohistochemistry, Lung, Carcinoma, Metastasis, Pathology, Clinical significance

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