Clinical analysis of chromosomal abnormality of 52 cases of female patients with infertility

Objective:To study the relationship between chromosome aberrances and their phenotype effect by clinical karyotype analysis of 52 cases of female patients with infertility.Methods:Peripheral blood lymphocyte culture and conventional chromosome analysis by G-band were conducted.Results:In 52 cases of female patients with chromosome aberrance,abnormal euchromosome structure accounted for 67.31%.The number of sex chromosome abnormalities and abnormal sex chromosome structure accounted for 23.07% and 9.62%,respectively.Among these cases patients repeatedly spontaneous abortion,fetal death and terata accounted for 55.77% and 11.54%,repeatedly.The number of female apparatus abnormality accounted for 32.69%.Chromosome karyotype abnormalities were comprised of the 3rd,4th,6th,7th,8th,9th,10th,13th,14th,15th,21st,22nd,X and Y Chromosomes among 52 cases.Conclusion:Chromosome aberrance played an important role in female infertility.Chromosome examination should be performed to exclude the possibility of chromosome aberrances in patients with obstinate infertility.