Clinical Investigation and Chromosomal Analysis of 1387 Cases of Male Patients with Infertility.

Objective: The objective was to investigate and analyze the relationship between chromosome abnormalities and the phenotype effect of 1387 male patients with infertility.Methods: Peripheral blood lymphocyte culture and conventional chromosome analysis by G-band was conducted.Results: In 249 cases of male patients with chromosome abnormalities,the case numbers of euchromosome abnormalities were 127 and accounted for 51.00%.The number of sex chromosome abnormalities and sex chromosome structure abnormalities were 28 and 94,respectively,and accounted for 11.24% and 37.76%,respectively.Among these cases patients with azoospermia and oligospermia were 17.27% and 15.66% respectively.To their spouses,repeatedly spontaneous abortion,fetal death accounted for 49.80%,terata accounted for 15.66%,and sexual organs abnormality accounted for 1.61%.Chromosome abnormalities were comprised of the 1st,2nd,3rd,4th,5th,6th,7th,9th,10th,13th,14th,15th,18th,21st,22nd and Y chromosome among 249 cases.Conclusion: Chromosome aberrance played an important role in male infertility.Chromosome examination should be performed to exclude the possibility of chromosome aberrances in patients with obstinate infertility.