Distribution and drug resistance of pathogens of blood culture from 2009 to 2011

Objective To learn the distribution and drug resistance of pathogens from blood culture specimens. Method The distribution and antimicrobial susceptibility test results of pathogens from positive blood culture specimens in the First Affiliated Hospital of Sun Yat-sen University were analyzed retrospectively. Results A total of 1 236 bacterial strains were isolated, which included 666(53.9%) Gram-negative bacillius and 570(46.1%) Gram-positive bacteria isolates.Escherichia coli(22.1%),Coagulase negative staphylococci(22.1%), Klebsiella pneumonia(9.2%), Staphylococcus aureus(7.0%) and Pseudomonas aeruginosa(5.7%) were the top five most common isolates. The incidences of Extended Spectrum β Lactamase(ESBLs) of E.coli and K.pneumoniae isolates were 61.6% and 37.9%, respectively. The resistance rates to several antibiotics of Acinetobacter baumannii were high. The resistance rates to Vancomycin and Linezolid of Gram-positive coccus were low. The incidence of Methicillin-resistant Staphylococcus aureus(MRSA) and Methicillin-resistant staphylococcus coagulase-negative(MRSCON) were 46.3% and 89.9%, respectively. Conclusions Gram-negative bacillius were predominant among pathogens from blood culture, and the main pathogens showed high drug resistance. We should pay attention to the distribution and drug resistant analysis of the isolated pathogens, and provide rationale of the use of antibiotics.