Experimental Study on Kangganqian Decoction in Rats with Liver Fibrosis

Objective: To investigate the effect of Kangganqian decoction in the Prevention of liver fibrosis through the rat model and to discuss its mechanism Method: The rat model of liver fibrosis was induced by intraperitoneal injection of DMN They were treated with Kangganqian decoction or colchicines as positive control The histological changes were observed with microscope The levels of ALT、AST、ALB、GLB、HA、LN、PCIII、IV C in serum were determined to reveal the event of liver damage Results: Kangganqian decoction significantly reduced the levels of ALT、AST、HA、LN、PCIII、IV C and improved the level of ALB in serum Pathological examination suggested with the degree of liver fibrosis was obviously relieved after the treatment of Kangganqian decoction Conclusion:Kangganqian decoction has preventive effect on liver fibrosis in the rats induced by DNM