Association between polymorphism of intercellular adhesion molecule-1 gene K469E and coronary heart disease

Objective:To study the polymorphism of intercellular adhesion molecule-1(ICAM-1) gene K469E in coronary heart disease(CHD) and healthy population, and to analyze association the serum level and genotypes of ICAM-1 with CHD.Methods:Using the PCR-RFLP method, the ICAM-1 gene K469E polymorphism in 225 CHD patients and 230 healthy controls were detected, and the serum level of ICAM-1 was determined by enzyme-linked immunosorbent assay(ELISA).Results:The CHD group showed significantly higher serum levels of ICAM-1 than control group(P0.01), the ICAM-1 gene K469E polymorphism was significantly difference between CHD group and control group. The relative risk suffered from CHD of E allele was 1.430 times of the K allele. The relative risk suffered from acute myocardial infarction(AMI) of E allele was 1.816 times of the K allele.Conclusion:The ICAM-1 gene K469E polymorphism is significantly associated with the occurrence, development and the severity of CHD, and K allele may be a genetic risk factor of CHD.