EXPRESSION OF C-erbB-2 GENE,MULTIDRUG-RESISTANCE GENE(P-gp) ANG THEIR INTERRELATIONSHIP TO ER IN HUMAN BREAST CANCER

Objective To observe the protein expression of C-erbB-2 gene and multidrug resistance gene1/P-glycoprotein(MDR1/P-gp) in human breast cancer and to explore their interrelationships to estrogen receptors(ER).Methods ER,C-erbB-2 protein and MDR1(P-gp) were detected in formalin2fixed,paraffin embedded tissues from 162 postoperative patients with breast cancer by immunohistochemical stain(SP).During this period,they were not treated by chemotherapy.Results of detection were analyzed statistically.Results Positive rate of ER,C-erbB-2 protein and MDR1/P-gp expression were 53.7%,37.0% and 27.7%,respectively.The positive rate of ER expression was higher in well differentiated and axillary lymph node negative breast cancer.The positive rate of C-erbB-2 expression was higher in poor differentiated breast cancer(P0.05).The positive rate of C-erbB-2 and MDR1(P-gp)expression was significantly higher in axillary lymph node positive breast cancer.The positive rate of C-erbB-2 expression was correlate with that of MDR1(P-gp),while correlate inversely with that of ER in human breast cancer.Conclusion Certain degree of interrelationship exists among ER, C-erbB-2 gene and MDR1(P-gp) in human breast cancer.Combined detection might be useful for the estimate of prognosis and the establishment of synthetical therapy regimen in breast cancer.