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Expression of ER, PR and C-erbB-2 in breast cancer and their clinical significance

Liu Ron

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Abstract

Objective To investigate the expression and clinical significance of ER, PR and C-erbB-2 in breast cancer. Methods 82 cases of primary breast cancer were examined for ER, PR and C-erbB-2 by immunohistochemical S-P methods. Results The expressions of ER, PR and C-erbB-2 were 54.9 %, 40.2 %, 47.6 % respectively. There was a negative correlation between ER and C-erbB-2(P 0.01). The expressions of C-erbB-2 was significantly correlated with tumor size(P 0.01). Conclusions For breast cancer, C-erbB-2 positive might serve as an indicator for poor prognosis, but ER and PR positive expression were indicators for a good prognosis.

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What this paper is about

Objective To investigate the expression and clinical significance of ER, PR and C-erbB-2 in breast cancer. Methods 82 cases of primary breast cancer were examined for ER, PR and C-erbB-2 by immunohistochemical S-P methods. Results The expressions of ER, PR and C-erbB-2 were 54.9 %, 40.2 %, 47.6 % respectively. There was a negative correlation between ER and C-erbB-2(P 0.01). The expressions of C-erbB-2 was significantly correlated with tumor size(P 0.01). Conclusions For breast cancer, C-erbB-2 positive might serve as an indicator for poor prognosis, but ER and PR positive expression were indicators for a good prognosis.

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Available abstract

Objective To investigate the expression and clinical significance of ER, PR and C-erbB-2 in breast cancer. Methods 82 cases of primary breast cancer were examined for ER, PR and C-erbB-2 by immunohistochemical S-P methods. Results The expressions of ER, PR and C-erbB-2 were 54.9 %, 40.2 %, 47.6 % respectively. There was a negative correlation between ER and C-erbB-2(P 0.01). The expressions of C-erbB-2 was significantly correlated with tumor size(P 0.01). Conclusions For breast cancer, C-erbB-2 positive might serve as an indicator for poor prognosis, but ER and PR positive expression were indicators for a good prognosis.

Key concepts: Breast cancer, Immunohistochemistry, Clinical significance, Medicine, Internal medicine, ErbB, Oncology, Cancer

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Expression of ER, PR and C-erbB-2 in breast cancer and their clinical significance — Research Paper | ScholarLens