Changes of Serum Levels of Interleukin-11 and Tumor Necrosis Factor-Alpha in Relation to the Severity of Acute Pancreatitis

Objective:To study the correlation between the serum levels of interleukin(IL)-ll/tumor necrosis factor(TNF)-o and the severity of acute pancreatitis(AP).Methods:A total of 68 AP cases,including 46 mild acute pancreatitis(MAP) cases and 22 severe acute pancreatitis(SAP) cases,were involved in this study,and peripheral venous blood samples were extracted at the 1st,3rd,7th,and 14th days respectively admitted to our hospital,then the serum levels of TNF-αand IL-11 were assayed by ELISA.Results:Compared with that respectively in control and MAP groups,TNF-a as well as IL-11 levels in the group of SAP increased on the 1st,3rd,and 7th days(P0.05,P0.01),but both indices decreased to normal level at the 14th day. Conclusion:The increasing of TNF-a level is positively correlated to the severity of AP,and its increasing occurs in the early days.But that of IL-11 level is negatively correlated to the severity of AP,and doesn't increase in the early days.