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2009•China Medical HeraldRequires access

Significance and serum levels of Th17 related cytokines IL-17,IL-6 and TNF-α in patients with acute pancreatitis

Changchun Gao

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Abstract

Objective:To investigate the significance and serum levels of Th17 related cytokines interleukin-17(IL-17),IL-6,and tumor necrosis factor α(TNF-α) in patients with acute pancreatitis.Methods:ELISA assay was used to determine the serum levels of IL-17,IL-6 and TNF-α of 19 patients with severe acute pancreatitis(SAP),28 patients with mild acute pancreatitis(MAP) and 21 cases of health people.Results:The levels of IL-17,IL-6 and TNF-α of SAP group and MAP group were significantly higher than those of control group.The levels of IL-17,IL-6 and TNF-α of SAP group were significantly higher than those of MAP group(P0.01).The level of IL-17 was positively correlated with the level of IL-6 and the level of TNF-α(r=0.51,P0.01;r=0.46,P0.01).The level of IL-6 was positively correlated with the levels of TNF-α(r=0.55,P0.01).Conclusion:The upregulation of Th17 may be involved in the development and aggravation of acute pancreatitis.

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Objective:To investigate the significance and serum levels of Th17 related cytokines interleukin-17(IL-17),IL-6,and tumor necrosis factor α(TNF-α) in patients with acute pancreatitis.Methods:ELISA assay was used to determine the serum levels of IL-17,IL-6 and TNF-α of 19 patients with severe acute pancreatitis(SAP),28 patients with mild acute pancreatitis(MAP) and 21 cases of health people.Results:The levels of IL-17,IL-6 and TNF-α of SAP group and MAP group were significantly higher than those of control group.The levels of IL-17,IL-6 and TNF-α of SAP group were significantly higher than those of MAP group(P0.01).The level of IL-17 was positively correlated with the level of IL-6 and the level of TNF-α(r=0.51,P0.01;r=0.46,P0.01).The level of IL-6 was positively correlated with the levels of TNF-α(r=0.55,P0.01).Conclusion:The upregulation of Th17 may be involved in the development and aggravation of acute pancreatitis.

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Available abstract

Objective:To investigate the significance and serum levels of Th17 related cytokines interleukin-17(IL-17),IL-6,and tumor necrosis factor α(TNF-α) in patients with acute pancreatitis.Methods:ELISA assay was used to determine the serum levels of IL-17,IL-6 and TNF-α of 19 patients with severe acute pancreatitis(SAP),28 patients with mild acute pancreatitis(MAP) and 21 cases of health people.Results:The levels of IL-17,IL-6 and TNF-α of SAP group and MAP group were significantly higher than those of control group.The levels of IL-17,IL-6 and TNF-α of SAP group were significantly higher than those of MAP group(P0.01).The level of IL-17 was positively correlated with the level of IL-6 and the level of TNF-α(r=0.51,P0.01;r=0.46,P0.01).The level of IL-6 was positively correlated with the levels of TNF-α(r=0.55,P0.01).Conclusion:The upregulation of Th17 may be involved in the development and aggravation of acute pancreatitis.

Key concepts: Medicine, Acute pancreatitis, Tumor necrosis factor alpha, Pancreatitis, Interleukin 6, Internal medicine, Gastroenterology, Tumor necrosis factor α

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