Effect of Sanshen Fang on Oxygen Radicals and Gastric Mucous Membrane Tissue in Rats with Chronic Atrophic Gastritis

Objective: to explore the functional mechanism of Sanshen Fang in treating chronic atrophic gastritis.Methods: The rats were randomly divided into control group,model group,Weimeisu group,Sanjiu Weitai group,high-dose of Sanshen Fang group and low-dose group,models made by composite factors.The experiment lasting for 8 weeks was to detect the changes of serum SOD activity and MDA content,and to observe the gastric mucous membrane tissue change.Results: Compared with control group,MDA content of model group increased significantly,SOD activity decreased significantly(P0.01);Epithelial cells of gastric mucous membrane had degeneration,necrosis and abscission,glands saw atrophy to different degrees,and there were a great deal of inflammatory cell infiltration.Compared with model group,MDA of treatment groups decreased and SOD increased(P0.01 or P0.05);Morphology indicated that gastric mucous membrane tissues were improved greatly.Conclusion: Sanshen Fang can reinforce SOD activity,decrease MDA content,clear oxygen radicals,has the action of antioxidation,and can improve gastric mucous membrane pathological appearance.