2013•Liaoning zhongyi zazhiRequires access
Research on p53 Mechanism of Weiweikang Reversing Chronic Atrophic Gastritis
Cheng Ya
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Abstract
Objective:To discuss the mechanism of Weiweikang reversing chronic atrophic gastritis.Methods:18 rats from 70 SD rats were randomly selected out as normal control group(normal group).The remaining 72 rats were made CAG model with the multiple stimulations for 6 weeks.The remaining 64 rats which were modeled successfully were randomly divided into four groups such as model group,Weiweikang large dose group,Weiweikang small dose group and Sanjiu Weitai group.The groups were injected 0.9% saline,Weiweikang high potency decoction,Weiweikang low potency decoction and Sanjiu Weitai suspension,once a day.After 30 days,the gastric mucosa pathological changes and the expression of mutant p53 were observed.Results:There was no significant differentiation of gastric mucosa pathematology in model group.The expression of mutant p53 made a significant increase compared with model group(P 0.01).The therapeutic drugs all could significantly improve gastric mucosa atrophy and reduce the expression of the mutant p53 and compared with the model group there was obvious difference(P 0.01).The average optical density of mutant p53 in Weiweikang large dose group was minimum,with significant difference compared to the other therapeutic groups(P 0.01).Conclusion:Weiweikang can improve and reverse the gastric atrophy of experimental atrophic gastritis of rats,which related to dose.Its mechanism may be related with restraining cell proliferation.