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2006•Shandong Daxue er-bi-hou-yan xuebaoRequires access

Significance of Fas and Bcl-2 expressions in nasal polyps

Hai Yuan

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Abstract

Objective: To study the expressions of Fas and Bcl-2 in nasal polyps and explore the relationship between the two apoptosis-related proteins in formation of nasal polyps.Methods: Expressions of Fas and Bcl-2 were detected with S-P immunohistochemical method in 36 nasal polyps and 19 inferior turbinates.Results:(1) The expression of Fas in epithelial cells and epithelial cells of glands was significantly lower in nasal polyps than in inferior turbinates((P)0.05);(2) The expression of Bcl-2 in epithelial cells and epithelial cells of glands was significantly higher in nasal polyps than in inferior turbinates(P0.05);(3) The expressions of Fas and Bcl-2 had no correlation with each other in epithelial cells of nasal polyps(P0.05).Conclusion:(1) Fas and Bcl-2 may play important role in the occurrence and progression of nasal polyps;(2) No relationship is found between Fas and Bcl-2 in inhibiting the epithelial cells of glands of nasal polyps.

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What this paper is about

Objective: To study the expressions of Fas and Bcl-2 in nasal polyps and explore the relationship between the two apoptosis-related proteins in formation of nasal polyps.Methods: Expressions of Fas and Bcl-2 were detected with S-P immunohistochemical method in 36 nasal polyps and 19 inferior turbinates.Results:(1) The expression of Fas in epithelial cells and epithelial cells of glands was significantly lower in nasal polyps than in inferior turbinates((P)0.05);(2) The expression of Bcl-2 in epithelial cells and epithelial cells of glands was significantly higher in nasal polyps than in inferior turbinates(P0.05);(3) The expressions of Fas and Bcl-2 had no correlation with each other in epithelial cells of nasal polyps(P0.05).Conclusion:(1) Fas and Bcl-2 may play important role in the occurrence and progression of nasal polyps;(2) No relationship is found between Fas and Bcl-2 in inhibiting the epithelial cells of glands of nasal polyps.

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Available abstract

Objective: To study the expressions of Fas and Bcl-2 in nasal polyps and explore the relationship between the two apoptosis-related proteins in formation of nasal polyps.Methods: Expressions of Fas and Bcl-2 were detected with S-P immunohistochemical method in 36 nasal polyps and 19 inferior turbinates.Results:(1) The expression of Fas in epithelial cells and epithelial cells of glands was significantly lower in nasal polyps than in inferior turbinates((P)0.05);(2) The expression of Bcl-2 in epithelial cells and epithelial cells of glands was significantly higher in nasal polyps than in inferior turbinates(P0.05);(3) The expressions of Fas and Bcl-2 had no correlation with each other in epithelial cells of nasal polyps(P0.05).Conclusion:(1) Fas and Bcl-2 may play important role in the occurrence and progression of nasal polyps;(2) No relationship is found between Fas and Bcl-2 in inhibiting the epithelial cells of glands of nasal polyps.

Key concepts: Nasal polyps, Immunohistochemistry, Medicine, Turbinates, Pathology, Apoptosis, Mucous membrane of nose, Nose

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