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2002•Ningxia Medical JournalRequires access

Expression and significance of Bcl-2 in nasal polyps

Liwei Xie

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Abstract

Objectives To study the expression and significance of Bcl-2 and PCNA(Proliferating cell nuclear antigen) in nasal polyps.Methods Expression of Bcl-2 protein and PCNA were prospectively detected with immunohistochemistry in 12 nasal polyps and 10 inferior turbinates.Results The Bcl-2 protein and PCNA positivity in epithelial cell was significantly higher in nasal polyps than in inferior turbinats(P0.05).Conclusions Epithelial cell proliferation and apoptosis inhibition in nasal polyps may be important in formation of nasal polyps.

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Objectives To study the expression and significance of Bcl-2 and PCNA(Proliferating cell nuclear antigen) in nasal polyps.Methods Expression of Bcl-2 protein and PCNA were prospectively detected with immunohistochemistry in 12 nasal polyps and 10 inferior turbinates.Results The Bcl-2 protein and PCNA positivity in epithelial cell was significantly higher in nasal polyps than in inferior turbinats(P0.05).Conclusions Epithelial cell proliferation and apoptosis inhibition in nasal polyps may be important in formation of nasal polyps.

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Available abstract

Objectives To study the expression and significance of Bcl-2 and PCNA(Proliferating cell nuclear antigen) in nasal polyps.Methods Expression of Bcl-2 protein and PCNA were prospectively detected with immunohistochemistry in 12 nasal polyps and 10 inferior turbinates.Results The Bcl-2 protein and PCNA positivity in epithelial cell was significantly higher in nasal polyps than in inferior turbinats(P0.05).Conclusions Epithelial cell proliferation and apoptosis inhibition in nasal polyps may be important in formation of nasal polyps.

Key concepts: Proliferating cell nuclear antigen, Nasal polyps, Immunohistochemistry, Medicine, Pathology, Apoptosis, Cell growth, Cell

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