Clinical value of serum tumor marker in early diagnosis ovarian cancer

Objective: To evaluate the value of serum human epididymis protein 4( HE4),cancer embryonic antigen( CEA),carbohydrate antigen( CA125,CA19-9,CA153),alpha fetoprotein( AFP) and β-human chorionic gonadotrophin( β-HCG) in ovarian cancer early diagnosis. Methods: Abbott Architect i2000 SR was used to detect the levels of preoperative serum tumor markers( n = 7)in ovarian cancer group,benign ovarian tumor group and the normal control( each n = 60). Results: The levels of serum HE4,CA125,CA199,CEA,CA153,AFP and β-HCG in ovarian cancer group were markedly higher than the benign ovarian tumor group and the control group. There was statistically significant difference( P 0. 05). The diagnosis of ovarian cancer tumor markers were high specificity,but sensitivity was not high except HE4( 76. 67%) and CA125( 68. 33%). With Youden Index,the area under curve of ROC,the HE4 was demonstrated higher specificity,sensitivity and accuracy. There was also medium diagnostic value of CA125,CA199 and CEA for ovarian cancer. The sensitivity of ovarian cancer diagnosis is raised by combined assay with serum tumor marker,but the specificity would be reduced accordingly. HE4,CA125,CA199 and CEA combined detection is considered the best. Conclusion: CA153,AFP andβ-HCG have lowered diagnosis for ovarian cancer. HE4,CA125,CA199 and CEA combined detection could significantly improve specificity,sensitivity and accuracy in the early diagnosis of ovarian cancer.