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The expression of urokinase-type plasminogen activator and its receptor in human glioma

Zhou Dai

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Abstract

Objective To study the expression of urokinase type plasminogen activator and its receptor in gliomas, and analysis the relationship between uPA/uPAR expression and the grade of human gliomas. Methods In surgical sample of 49 patients with glioma, 3 glioma cell lines and 12 samples of normal brain tissues obtained from craniocerebral injury surgery, the level of uPA/uPAR mRNA were studied using semi quantitative reverse transcription polymerase chain reaction. Results Along with the rise of glioma grade, the uPA mRNA and uPAR mRNA expression rate and level were also upregulated. U251 and other 2 glioma cells had a high level of uPA and uPAR mRNA, but the rate and level of uPA and uPAR mRNA of normal brain tissues were extremely lower. Conclusions The plasminogen system activation was quite higher in gliomas. The high level of uPA and uPAR mRNA reflecte a malignant biological behavior of glioma cells.

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Objective To study the expression of urokinase type plasminogen activator and its receptor in gliomas, and analysis the relationship between uPA/uPAR expression and the grade of human gliomas. Methods In surgical sample of 49 patients with glioma, 3 glioma cell lines and 12 samples of normal brain tissues obtained from craniocerebral injury surgery, the level of uPA/uPAR mRNA were studied using semi quantitative reverse transcription polymerase chain reaction. Results Along with the rise of glioma grade, the uPA mRNA and uPAR mRNA expression rate and level were also upregulated. U251 and other 2 glioma cells had a high level of uPA and uPAR mRNA, but the rate and level of uPA and uPAR mRNA of normal brain tissues were extremely lower. Conclusions The plasminogen system activation was quite higher in gliomas. The high level of uPA and uPAR mRNA reflecte a malignant biological behavior of glioma cells.

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Available abstract

Objective To study the expression of urokinase type plasminogen activator and its receptor in gliomas, and analysis the relationship between uPA/uPAR expression and the grade of human gliomas. Methods In surgical sample of 49 patients with glioma, 3 glioma cell lines and 12 samples of normal brain tissues obtained from craniocerebral injury surgery, the level of uPA/uPAR mRNA were studied using semi quantitative reverse transcription polymerase chain reaction. Results Along with the rise of glioma grade, the uPA mRNA and uPAR mRNA expression rate and level were also upregulated. U251 and other 2 glioma cells had a high level of uPA and uPAR mRNA, but the rate and level of uPA and uPAR mRNA of normal brain tissues were extremely lower. Conclusions The plasminogen system activation was quite higher in gliomas. The high level of uPA and uPAR mRNA reflecte a malignant biological behavior of glioma cells.

Key concepts: Urokinase receptor, Glioma, Plasminogen activator, Messenger RNA, Cancer research, Urokinase, Receptor, Molecular biology

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The expression of urokinase-type plasminogen activator and its receptor in human glioma — Research Paper | ScholarLens