2005•Clinical neurosurgeryRequires access

Expressions and Significances of Urokinase-type Plasminogen Activator and its Receptor in Human Gliomas

Hongyan Zhao

Abstract

Objectives To study the expressions of urokinase-type plasminogen activator (uPA) and its receptor (uPAR) in the gliomas, and to analysis the relationship between uPA and uPAR expressions and the grade of human gliomas. Methods The levels of uPA and uPAR protein expressions were determined by immunohistochemical technique in 58 cases of the gliomas and 10 samples of the normal brain tissue. Results The expressions of uPA and uPAR were not detected in normal brain tissures, and positively correlated with the pathological grade of the gliomas (P0.01). Conclusions The high levels of uPA and uPAR expressions may reflect a malignant biological behavior of the glioma cells.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Urokinase receptor, Plasminogen activator, Urokinase, Glioma, Immunohistochemistry, Receptor, Medicine, Cancer research