Effect of Electroacupuncture on Hemorheology and Inflammatory Factors of Hyperlipidemia Model Rats

Objective:To observe the effect of electroacupuncture(EA)at the Fenglongpointon hemorheology and inflammatory factors MCP-1,IL-1β,and IFN-γof rats with hyperlipemia,and tostudy the role of electroacupuncture in treating HLP.Methods:Forty healthy male SD rats were selected and randomly divided into four groups:the blank control group(Group A),the hyperlipemia model group(Group B),electroacupuncture group 1(Group C,high fat diet+EA),and the electroacupuncture group 2(Group D,normal diet+EA),with 10 rats in each.Blood lipids and blood rheology indicators were assayed.The macrophages were isolated for determination of MCP-1,IL-1β,and IFN-γby flow cytometry(FCM).Results:Compared with Group A,TC and LDL-C of hyperlipemia rats were much higher(P0.01),HDL-C decreased significantly(P0.01).After EA treatment,the contents of TC and LDL-C significantly decreased(P0.01).Compared with those in Group A,hemorheology indexes of the Group B had obvious difference(P0.05,P0.01),while those in Group D had no significant difference(P0.05).Compared with Group B,hemorheology had significantly increased in Group C and Group D,especially in the Group D(P0.01).Compared with Group A,the MCP-1,IL-1β,and IFN-γof Group B significantly increased(P0.01),while anti-inflammatory factor IL-10 decreased significantly(P0.01).Compared with Group B,except MCP-1,the other inflammatory factors showed no obvious difference(P0.05).Compared with those of Group A,the inflammatory factors of Group C and D obviously decreased(P0.05 and P0.01,respectively).Compared with that of Group B,the IL-10 of GC and GD significantly increased(P0.01).Conclusion:Electroacupuncture at the Fenglongpoint can decrease the changes in TC,LDL-C,and hemorheology in rat with hyperlipemia and reduce the content of MCP-1,IL-1β,and IFN-γ,while increasing the content of IL-10,so as to achieve therapeutic effect on hyperlipidemia.