Effect of electroacupuncture at "Fenglong"(ST40) on ICAM-1 and MCP-1 in macrophages of rats with hyperlipidemia

Objective:To study the effect of electroacupuncture at the Fenglong on inflammatory factors ICAM-1 and MCP-1 of rats with hyperlipemia(HLP).Methods:Fifty health male SD rats were randomly divided into 5 groups:normal control group(A),model control group(B),model+normal diet group(C),model+electroacupuncture group(D),model+normal diet+electroacupuncture group(E)(n=10 each group).After intervention for 60 days,blood fat and the expression of ICAM-1 and MCP-1 were detected.Results:As compared with group A,the contents of TC and LDL-C were significantly increased and HDL-C significantly reduced in group B(P0.05,0.01).The contents of TC and LDL-C were significantly decreased in groups C and D as compared with group B,and those in groupsB,C,D were significantly higher than in group A(all P0.01).As compared with groups B and C,the contents of TC and LDL-C were significantly redeuced in group E(all P0.01).The number of macrophages,the expression levels of ICAM-1 and MCP-1 in groups B,C,D were obviously increased as compared with group A(P0.05,0.01),more significantly in groups B and C(all P0.01).The number of macrophages,and the expression levels of ICAM-1 and MCP-1 in group E were obviously decreased as compared with group B and C(all P0.01).Conclusion:Electroacupuncture at Fenglong can notably decrease the contents of TC and LDL-C,the number of macrophages,and the expression levels of ICAM-1 and MCP-1,thereby have therapeutical effect on hyperlipemia.