Clinical significance of MAGE-A3 and AKAP-4 in non-small cell lung carcinoma

Objective To determine the expression of MAGE-A3 and AKAP-4 in patients with non-small cell lung carcinoma(NSCLC) and to evaluate the possibility of exploiting them as biomarkers for diagnosis.Methods Indirect enzyme immunohistochemical method was performed on paraffin-embedded tissues from 45 patients with NSCLC,and the correlations between antigens expression and histological types as well as lymph node metastasis were evaluated.Results In 45 tumor samples,the sensitive of MAGE-A3 and AKAP-4 detection was 62.2% and 73.3%,respectively.Combined detection of both MAGE-A3 and AKAP-4 can significantly increase the sensitivity to 91.1%(P0.05).There was no significance difference in the expression of MAGE-A3 and AKAP-4 between lung adenocarcinoma and squamous cell lung carcinoma.The expression of MAGE-A3 and AKAP-4 was not related to lymph node metastasis.Conclusion Both MAGE-A3 and AKAP-4 can be used to further increase the sensitivity of NSCLC diagnosis.