Expression of MAGE-A10 protein and its clinical significance in human lung cancer

Objective: To explore the expression and the clinical significance of MAGE-A10 in human lung cancer. Methods: By using tissue array and S-P immunohistochemical methods with anti-MAGE-A10 monoclonal antibody, the expression of MAGE-A10 protein in 65 cases lung cancer was investigated and the correlation of MAGE-A10 expression with histological types and pathological grades was also evaluated. Results: The positive expression rates of MAGE-A10 were 36.4% in small cell lung carcinoma, 76.5% in squamous cell lung carcinoma and 40.0% in lung adenocarcinoma repectively, but no positive case can be found in large cell lung carcinoma and bronchioloalveolar carcinoma. It was no statistical significance between the expression ratio of MAGE-A10 protein in the small cell lung carcinoma(SCLC) and non-small cell lung carcinoma(NSCLC). The correlation of pathological grades in both the squamous cell carcinoma groups and the adenocarcinoma groups with expression of MAGE-A10 was also not been found. Conclusion: The expression ratio of MAGE-A10 in squamous cell lung carcinoma was the highest, followed by that in lung adenocarcinoma and SCLC suggesting that MAGE-A10 might be used as an useful marker in pathological diagnosis as well as a potential target in biological therapy of lung cancer.