2012•Zhonghua shiyan waike zazhiRequires access
Expression and significance of melanoma antigen melanoma andgen-D4 in noil-small cell lung caner
Qinyun Ma, Zhiming Chen, Liewen Pang, Yongjun Zhu, Gang Chen, Ji Chen
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Abstract
Objective To study the differential expression of melanoma antigen (MAGE)-D4 gene in non-small cell lung caner (NSCLC) and normal lung tissue.Methods Fifty-four NSCLC patients were classified by age,sex,smoke history,tumor size,pathologic type,cytodifferentiation,lymphatic metastssis.MAGE-D4 gene expression patterns were detected in NSCLC.Results The expression of MAGE-D4 gene in NSCLC was higher than that in normal lung tissue ( 1.74 vs 0.55,P ＜ 0.05 ).The expression level has no relationship with age,sex,smoke history and tumor size.The squamous cell carcinoma had a higer expression than adenocacinoma ( 1.99 vs 1.27,P ＜ 0.05 ).The expression in poorly differentiated tumor was higher than that in moderately differentiated tumor ( 2.96 vs 1.01 P ＜ 0.05 ).The expression in NSCLC with lymphatic metastasis was higher than in that without lymphatic metastasis (2.07 vs 1.42,P ＜0.05 ).Conclusion MAGE-D4 gene has a higher expression level in NSCLC and its expression may follow a certain rule.The MAGE-D4 gene could be potentially a specific NSCLC antigen.
Key words:
Melanoma antigen-D4 gene; Non-small cell lung cancer