Distribution and drug resistance of Candida from respiratory tract specimens

Objective To investigate the distribution and drug resistance of Candida spp.from respiratory tract of inpatients in recent years,and provide reference for rational use of antifungal agents.Methods Respiratory specimens from 38 326 inpatients in several hospitals between 2007 and 2011 were cultured by Sabouraud agar culture,and Candida were identified by VITEK 32 or FUNGS CA20;antifungal susceptibility testing of Candida was performed by ATB FUNGUS 3.WHONET5.4 software was used for analyzing antifungal susceptibility testing result.Results A total of 2 745(7.16%)Candida isolates were isolated,including 2 036(74.17%)isolates of Candida albicans,348(12.68%) of Candida tropicalis,118(4.30%)of Torulopsis glabrata,57(2.08%) of Candida parapsilosis,57(2.08%)of Candida krusei,and 129(4.70%)of other types of Candida.Resistant rate of fungi from high to low were itraconazole,fluconazole,voriconazole,flucytosine and amphotericin B,χ2 test showed that drug resistance rate of all Candida to flucytosine,amphotericin B and fluconazole didn't change from 2007 to 2011(P0.05),while resistance rate to itraconazole and voriconazole increased(P0.05).Conclusion The major Candida spp.in respiratory infection are Candida albicans,the resistant rate to antifungal agent is increasing.