The correlation between the hs-CRP and P-selectin level and prognosis in CHD patients with depression

Objective:To analyze the relationship between depression and coronary heart disease(CHD),the levels of high sensitivity C reactive protein(hs-CRP)and P-selectin.To observe the major adverse cardiac events(MACE)in 1year follow-up.Method:All 336patients were selected and divided into control group,angina pectoris group,myocardial infarction group.The anxiety self-assessment scale analysis system was applied for evaluating the patients′depressive state.Hs-CRP and P-selectin levels were detected.Patients were followed up for 1 year to observe the incidence of MACE.Result:One hundred and nine patients(32.4%)were depression.Depression cases in control group,angina and myocardial infarction patients were 9(16.4%),43(28.1%)and 57(44.5%)respectively(all P0.05).Hs-CRP levels of depressed and non-depressed patients in control group,angina pectoris group and myocardial infarction group were(3.06±1.78)mg/L and(1.82±1.33)mg/L,(8.74± 7.23)mg/L and(4.61±4.26)mg/L,(12.21±7.23)and(9.30±6.82)mg/L respectively(all P0.05).Pselectin levels of depressed and non-depressed patients in control group,angina pectoris group,myocardial infarction group were(18.04±2.02)ng/L and(16.02±3.15)ng/L,(30.24±5.83)ng/L and(25.56±6.08)ng/L,(33.53±4.91)ng/L and(29.32±5.43)ng/L,respectively(all P0.05).Patients were followed up for 1year,and 34cases(31.2%)with depression occurred MACE,much higher than that without depression(39cases,17.2%)(P0.05).Conclusion:Depression is a risk factor of CHD and relates with the severity of CHD.Hs-CRP and P-selectin levels of depressed patients are significantly higher than those without depression.The incidence of 1-year follow-up MACE in patients with depression is obviously higher than that without depression.