Association between serum LDL-C levels and coronary artery changes in patients with coronary heart disease

Objectives To investigate the possible relation between the serum low density lipoprotein cholesterol(LDL-C)and coronary artery changes in patients with coronary heart disease (CHD). Methods Coronary angiography (CAG) was performed in 328 patients. The patients were divided into CHD group and control group. The serum levels of lipids were measured. According to the coronary number of stenosis, CHD group was further divided into 1-vessel group,2-vessel group and 3-vessel group according to the degree of coronary lesion, CHD group was further divided into light stenosis group, moderate stenosis group and severe stenosis group. Results The levels of total cholesterol(TC), LDL-C and triglyceride(TG) in CHD patients were significant higher than those in control subjects. The serum levels of TC and LDL-C were significantly related to CHD (P 0.01). The serum levels of TC and LDL-C were higher in the 2-vessel group and 3-vessel group than in the control group and 1-vessel group (P 0.01). The serum levels of TC and LDL-C were higher in the moderate stenosis group, severe stenosis group than in the control group and light stenosis group(P 0.01). Conclusions The increasing of TC and LDL-C is an associated with the stenosis degrees and lesion degrees of coronary artery in patients witth CHD which indicated that TC and LDL-C had clinical significance for evaluating the change of degree of coronary artery lesion. The levels of serum TG in patients with CHD is closely related with risk factors in CHD.