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Analysis of HPV genotypes in paraffin-embedded tissue of cervical cancer

Cui Jinhuan

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Abstract

Objective To investigate the distribution of HPV genotypes in paraffin-embedded tissues of cervical cancer in Foshan region.Methods 61 cervical cancer tissues were analyzed by genechip technique with 23 HPV genotypes.Results The total positive rate of HPV was 67%(41/61) in 61 cervical cancer tissues diagnosed by histopathology.Among 41 positive cases,HPV16 was 63.4%(26/41),with 29.2%(12/41) of HPV18,2.4%(1/41) of HPV33;4.8%(2/41) of mixed genatypes in which 1 case was HPV16/18 and the other was HPV16/59 respetively.Conclusions HPV16 and HPV18,with 95.3% of HPV positive genotypes in the cervical cancer tissues,are most prevalent in Foshan region.The results suggest that cervical cancer exist concentrated HPV genotynes.

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What this paper is about

Objective To investigate the distribution of HPV genotypes in paraffin-embedded tissues of cervical cancer in Foshan region.Methods 61 cervical cancer tissues were analyzed by genechip technique with 23 HPV genotypes.Results The total positive rate of HPV was 67%(41/61) in 61 cervical cancer tissues diagnosed by histopathology.Among 41 positive cases,HPV16 was 63.4%(26/41),with 29.2%(12/41) of HPV18,2.4%(1/41) of HPV33;4.8%(2/41) of mixed genatypes in which 1 case was HPV16/18 and the other was HPV16/59 respetively.Conclusions HPV16 and HPV18,with 95.3% of HPV positive genotypes in the cervical cancer tissues,are most prevalent in Foshan region.The results suggest that cervical cancer exist concentrated HPV genotynes.

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Available abstract

Objective To investigate the distribution of HPV genotypes in paraffin-embedded tissues of cervical cancer in Foshan region.Methods 61 cervical cancer tissues were analyzed by genechip technique with 23 HPV genotypes.Results The total positive rate of HPV was 67%(41/61) in 61 cervical cancer tissues diagnosed by histopathology.Among 41 positive cases,HPV16 was 63.4%(26/41),with 29.2%(12/41) of HPV18,2.4%(1/41) of HPV33;4.8%(2/41) of mixed genatypes in which 1 case was HPV16/18 and the other was HPV16/59 respetively.Conclusions HPV16 and HPV18,with 95.3% of HPV positive genotypes in the cervical cancer tissues,are most prevalent in Foshan region.The results suggest that cervical cancer exist concentrated HPV genotynes.

Key concepts: Cervical cancer, Histopathology, Genotype, Medicine, Pathology, Cancer, Oncology, Biology

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