Sequential mechanical ventilation for the treatment of acute respiratory distress syndrome caused by severe acute pancreatitis curative effect analysis

Objective To observe the clinical effect of invasive mechanical ventilation(IMV)-noninvasive positive airway pressure(cpap) double level(BiPAP) sequential therapy in severe acute pancreatitis(SAP) caused by acute respiratory distress syndrome(ARDS).Methods 125 cases of ARDS caused by SAP patients were randomly divided into two groups:observation group(n = 65) with IMV-BiPAP sequential therapy,the control group(n = 60) with IMV treatment only.We compared the situation of the two groups appearing window ARDS control,sequential treatment group tube drawing before and after 12 h noninvasive ventilation changes in vital signs,clinical indicators of the two groups after removal machine.Results The time and mean airway pressure(MAP),breathing rate(RR),heart rate(HR),acidity(pH),the arterial blood oxygen partial pressure(PaO2),CO2partial pressure(PaCO2) and inhaled oxygen concentration(FiO2) in two groups appeared window ARDS control,etc,are no significant difference(P 0.05).There were no significant change in vital signs and noninvasive ventilation index after sequential treatment group patients before extubation after 12 h(P 0.05).The invasive ventilation time and total time of mechanical ventilation,ICU time,hospitalization costs,ventilator associated pneumonia(VAP) incidence and mortality in observation group were significantly less than those of the control group(P 0.05).Conclusion IMV-BiPAP sequential ARDS caused by SAP showed obvious therapeutic effect,safe and reliable,is worthy of clinical popularization and application.