Clinical value of sequential mechanical ventilation in patients with acute respiratory distress syndrome caused by severe acute pancreatitis

Objective To investigate effect of invasive-noninvasive sequential mechanical ventilation on treating patients with acute respiratory distress syndrome caused by severe acute pancreatitis.Methods 72 cases of acute respiratory distress syndrome caused by severe acture pancreatitis in our hospital from May 2009 to May 2011 were randomly divided into two groups with 36 cases in each:treatment group (sequential mechanical ventilation group) and control group (invasive ventilation group).PaO2,PaCO2,and pH were measured before treatment and 16 hours after treatment in both groups.The mechanical ventilation duration,case fatality,curative ratio,side effect incidence were analyzed.Results The invasive ventilation duration in treatment group [(2.34 ± 1.24) days] was shorter than that in control group [(5.21-t-2.32) days,t =3.230,P ＜0.05].There was no statistical significance in total mechancial ventilation duriation between two groups [(4.38±2.15) days vs (4.25±2.35) days,t =3.230,P ＞0.05].The level of pH was improved at 16th hour in treatment group.The level of PaO2 in treatment group was superior to that in control group (t =3.440,P ＜0.05),and PaCO2 was superior too (t =5.125,P ＜0.05).The incidence of vetilation associated pneumonia in treatment group was lower than that in control group (8.3ooo vs 16.7％,x2 =15.644,P ＜ 0.05).Moreover,the curative ratio in treatment group (86.1％) was higher than that in conrol group (75.0％).Conclusions The invasive-noninvasive sequential mechanical ventilation is more effective in patients with acute respiratory distress syndrome caused by severe actue pancreatitis by shortening the time of invasive ventilation duration and decreasing the incidence and case fatality of ventilation associated pneumonia. Key words: Sequential mechanical ventilation;  Acute pancreatitis;  Acute respiratory distress syndrome