The correlation of serum and tissue vascular endothelial growth factor and human colorectal carcinoma

Purpose Try to find a reliable and atraumatic method to predict the progress and prognosis of human colorectal carcinoma. Methods The vascular endothelial growth factor (VEGF) levels in serums and tissues of 36 patients with colorectal carcinoma were measured by ELISA and immunohistochemistry, meanwhil 53 cases healthy volunteers were also measured as control group. The correlation of serum VEGF and tissue VEGF were especially analyzed. Results ①The level of serum VEGF in patients with colorectal carcinoma was significantly higher than that of control group( 813.14 ±511.87)μg/L versus (241.40±164.08)μg/L.②Serum VEGF was not correlated to sex, age, tumor site and histological type.③The levels of serum and tissue VEGF were positively correlated to tumor size, lymph-node involvement and liver or distant organs metastasis.④Serum VEGF and tissue VEGF were closely correlative. Conclusions ①Since the levels of serum and tissue VEGF were closely correlated with Dukes stage, they can be used as a good parameter to predict development and prognosis of colorectal carcinoma.②Since the levels of VEGF between serum and tissue were parallel, so serum VEGF measurement may be the substitution of tissue VEGF.