Clinical Study on Serum Vascular Endothelial Growth Factor in Human Colorectal Carcinoma

Objective： This study was designed to determine the serum vascular endothelial growth factor (VEGF)level in human colorectal carcinoma and analyze its clinical significance. Methods： The level of serum VEGF was measured by ELISA kit (R＆ D,SYSTEM INC,USA) in 82 patients with colorectal carcinoma and 30 normal persons as the control group. Results： The level of serum VEGF in colorectal carcinoma was significantly higher than that of normal control. The level of serum VEGF was positively correlated with tumor size, vessel invasion, lymph-node metastasis. With upgrading of clinical-pathological stage(Dukes stage), the level of VEGF increased significantly, but its relation to tumor site, histological type, age, and sex was not significant. Conclusion： The level of serum VEGF is closely correlated to invasion and metastasis of colorectal carcinoma. Serum VEGF assay may be used to preoperatively predict invasion and metastasis of colorectal carcinoma.