Analysis on Clinical Distribution and Drug Resistance of 277 Strains of Staphylococcus Aureus

Objective To investigate the clinical distribution and antibiotic resistance of Staphylococcus aureus.Methods Two hundred and seventy-seven strains of Staphylococcus aureus used in the test were mainly taken from sputum(35.74%) and fester(35.37%),and all the strains were isolated from ICU ward and orthopedics department(respectively 24.19%).Results Among the 277 strains of Staphylococcus aureus,there were 201 strains of methicillin-resistant Staphylococcus aureus(MRSA),with the detection rate of 72.56%,and the rest of the strains were methicillin sensitive staphylococcus aureus(MSSA).The results of sensitivity test of MRSA and MSSA to 16 kinds of antibiotics showed that the drug resistance rates of MRSA to oxacillin,penicillin,gentamicin,levalfloxacin,norfloxacin,and cotrimoxazole were significantly higher than those of MSSA to the six antibiotics,and the difference was statistically significant(P0.05).The rest ten showed no statistically significant difference(P0.05).Conclusions MRSA is an important pathogen of nosocomial infection.The drug resistance rates of MRSA to oxacillin,penicillin,erythromycin,levofloxacin,gentamicin,and cotrimoxazole are significantly higher than those of MSSA.