Analysis of drug resistance in 2012 and the antibiotic resistance changes in the last four years of Staphylococcus aureus from The First Affiliated Hospital of Guangdong College of Pharmacy

Objective To analyze the drug resistance in 176 strains of Staphylococcus aureus isolated from clinic in 2012 and the antibiotic resistance changes of Staphylococcus aureus in the last four years from The First Affiliated Hospital of Guangdong College of Pharmacy.Methods The pathogenic bacteria were evaluated by PHoenixTM100.Drug susceptibility test was carried out by MIC way.The results of all strains of Staphylococcus aureus during 2009 to 2012 were analysed by WHONET 5.4.Results 49.4% of the 176 strains of Staphylococcus aureus in 2012 were distributed mainly in the sputum and ICU had the highest detection rate with 26.7%.100 s trains of methicillin-resistant Staphylococcus aureus(MRSA) were detected which accounted for 56.8%.All strains were sensitive to vancomycin,linezolid and teicoplanin,and the resistance rate to other antibiotics of MRSA was higher than meticillin-sensitive Staphylococcus aureus(MSSA)(P 0.05).There was 5.1% detected rate of MRSA by oxacillin way less than that by cefoxitin way.All strains were sensitive to vancomycin,linezolid and teicoplanin in the last four years.The vancomycin geometric mean MICs of MRSA were 1.080、1.024、1.037、1.133 μg / ml,ang they were 0.804、0.840、0.818、 0.938 μg / ml of MSSA.There was a significant difference between MRSA strains and MSSA strains(P 0.01).MIC trends were not found(P 0.05).Conclusion Resistance of Staphylococcus aureus is quite serious,and MRSA has multi-drug-resistance.Vancomycin,linezolid and teicoplanin are still very sensitive.MIC trends of vancomycin were not found.