Effect of bartroxobin on platelet function of patients with acute ischemic stroke

Objective To observe the changes of platelet membrance glycoprotein and platelet leucocyte aggregates in the peripheral blood of patients with acute ischemic stroke after treatment with bartroxobin. Methods The treated group was given bartroxobin 20 BU for three day(28 cases); the control group was similarly treated but without bartroxobin(25 cases). The expression of platelet membrance glycoprotein Ⅱb Ⅲa complex α subunit(CD41), P selectin(CD62p), lysosomes membrance protein 53(CD63) and platelet lymphocyte, monocyte, neutrophil aggregates were measured by cytometry in consecutive patients(within 24 hours and 48, 72 hours after onset of stroke).Results Compared with the control group, the percentage of positive CD62p was elevated in bartroxobin treated group 48 hours after onset of stroke ( P 0.05). No difference in percentages of positive CD41, CD62p, CD63 and platelet leucocyte aggregates were detected 72 hours after onset of stroke.Conclusion Treatment of acute stroke with bartroxobin may lead to platelet activation, which implicates the necessity of giving anti platelet drug together with bartroxobin.