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Comparative Study of Zengye Decoction and Sini Decoction in Inhibiting Ventricular Remodeling

Chen Chang-xun

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Abstract

Objective:To investigate the influence of Zengye Decoction and Sini Decoction on ventricle remodeling.Methods:Ventricular remodeling models were induced by injection of isoproterenol in mice and constriction of abdominal aorta in rats.The effects of Zengye Decoction and Sini Decoction on the heart weight index,blood pressure,AngⅡ,ALD,ET and Hyp levels were assessed.Results:Compared with those of the normal or sham operated group,the heart weight index,blood pressure,the levels of AngⅡ,ET,Hyp in the myocardium and ALD in the blood serum were significantly increased in the model group.In group treated with Zengye Decoction,the heart weight index,blood pressure,the levels of AngⅡ,ET,Hyp in the myocardium and the serum level of ALD were decreased remarkably.Sini Decoction did not show such effects,except that it could decline the level of ET.Conclusions:Zengye Decoction has the effects on inhibiting ventricular remodeling.The mechanism may be related to decreasing the blood pressure and inhibiting neuroendocrine factors.Sini Decoction has no effects on inhibiting ventricular remodeling.

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What this paper is about

Objective:To investigate the influence of Zengye Decoction and Sini Decoction on ventricle remodeling.Methods:Ventricular remodeling models were induced by injection of isoproterenol in mice and constriction of abdominal aorta in rats.The effects of Zengye Decoction and Sini Decoction on the heart weight index,blood pressure,AngⅡ,ALD,ET and Hyp levels were assessed.Results:Compared with those of the normal or sham operated group,the heart weight index,blood pressure,the levels of AngⅡ,ET,Hyp in the myocardium and ALD in the blood serum were significantly increased in the model group.In group treated with Zengye Decoction,the heart weight index,blood pressure,the levels of AngⅡ,ET,Hyp in the myocardium and the serum level of ALD were decreased remarkably.Sini Decoction did not show such effects,except that it could decline the level of ET.Conclusions:Zengye Decoction has the effects on inhibiting ventricular remodeling.The mechanism may be related to decreasing the blood pressure and inhibiting neuroendocrine factors.Sini Decoction has no effects on inhibiting ventricular remodeling.

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Available abstract

Objective:To investigate the influence of Zengye Decoction and Sini Decoction on ventricle remodeling.Methods:Ventricular remodeling models were induced by injection of isoproterenol in mice and constriction of abdominal aorta in rats.The effects of Zengye Decoction and Sini Decoction on the heart weight index,blood pressure,AngⅡ,ALD,ET and Hyp levels were assessed.Results:Compared with those of the normal or sham operated group,the heart weight index,blood pressure,the levels of AngⅡ,ET,Hyp in the myocardium and ALD in the blood serum were significantly increased in the model group.In group treated with Zengye Decoction,the heart weight index,blood pressure,the levels of AngⅡ,ET,Hyp in the myocardium and the serum level of ALD were decreased remarkably.Sini Decoction did not show such effects,except that it could decline the level of ET.Conclusions:Zengye Decoction has the effects on inhibiting ventricular remodeling.The mechanism may be related to decreasing the blood pressure and inhibiting neuroendocrine factors.Sini Decoction has no effects on inhibiting ventricular remodeling.

Key concepts: Decoction, Ventricle, Medicine, Ventricular remodeling, Blood pressure, Internal medicine, Endocrinology, Heart failure

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