Effection of Sini decoction on serum Endothelin and Calcitonin gene-related peptide in congestive heart failure rat model

Objective To explore the clinical effect and machenism of Sini decoction on chronic congestive heart failture.Methods 40 of 50 Wistar rats wrere used to make congestive heart failure model by injection of adriamycin into the peritoneum with dose of 1 mg/kg in the second and the fourth day,2 mg/kg in the sixth and the eithth day,3 mg/kg in the tenth and the twelveth day,and the cumulative dose of adriamycin was 20 mg/kg.The other 10 Wistar rats were divided into the normal group.38 model rats were randomly divided into model control group,Captopril group and Sini decoction group.Results Compared with the normal group,serum CGRP level significantly decreased and ET level significantly increased.Compared with the model failure group,serum ET level significantly decreased and the level of CGRP significantly increased in the Sini decoction group and the Captopril group(P0.05).The degree of mycardial damage in the Sini decoction group was obviously lower than that in the model group.Conclusion Sini decoction can modify the nerval endocrine function of chronic heart failure rat and can antagonize the hyperactive nerval endocrine system.