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2010•Zhōnghuá yàoxué zázhìRequires access

Preparation of Solid Lipid Nanoparticles Loading Lappaconitine Hydrobromide by High Pressure Homogenization

Hou Yue-han

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Abstract

OBJECTIVE To prepare solid lipid nanoparticles loading lappaconitine hydrobromide (LH-SLN) by high pressure homogenization,and to study the main factors affecting the preparation of LH-SLN.METHODS The parameters of technology were determined,then the affecting factors of LH-SLN were studied.On the basis of the single factor exploration,the satisfactory formulation was selected by orthogonal design with high entrapment efficiency as standard.RESULTS The average entrapment efficiency of LH-SLN was 70.48%.CONCLUSION The technique of preparing LH-SLN by high pressure homogenization is feasible.

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What this paper is about

OBJECTIVE To prepare solid lipid nanoparticles loading lappaconitine hydrobromide (LH-SLN) by high pressure homogenization,and to study the main factors affecting the preparation of LH-SLN.METHODS The parameters of technology were determined,then the affecting factors of LH-SLN were studied.On the basis of the single factor exploration,the satisfactory formulation was selected by orthogonal design with high entrapment efficiency as standard.RESULTS The average entrapment efficiency of LH-SLN was 70.48%.CONCLUSION The technique of preparing LH-SLN by high pressure homogenization is feasible.

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Available abstract

OBJECTIVE To prepare solid lipid nanoparticles loading lappaconitine hydrobromide (LH-SLN) by high pressure homogenization,and to study the main factors affecting the preparation of LH-SLN.METHODS The parameters of technology were determined,then the affecting factors of LH-SLN were studied.On the basis of the single factor exploration,the satisfactory formulation was selected by orthogonal design with high entrapment efficiency as standard.RESULTS The average entrapment efficiency of LH-SLN was 70.48%.CONCLUSION The technique of preparing LH-SLN by high pressure homogenization is feasible.

Key concepts: Solid lipid nanoparticle, Hydrobromide, Homogenization (climate), Entrapment, Chemistry, Chromatography, Materials science, Nanoparticle

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