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Preparation of Solid Lipid Nanoparticles by Emulsification-evaporation Technique

Bo Wang

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Abstract

Objective:To prepare the solid lipid nanoparticles(SLN)by emulsification-evaporation technique,and to investigate the drug loading capacity of SLN.Methods:The influences of formulation and processing variables on the preparation and the quality of SLN were studied.The SLN containing Ketoprofen(KT-SLN)was prepared.The entrapment efficacy and drug release from SLN were assessed.Results:The mean size was(228.2±18.1)nm with polydispersity index of(0.217±0.022)and the zeta potential was-(21.4±0.6)mV.The best entrapment efficiency of KT-SLN was found to be(64.1±3.3)% and the release profile in vitro was best fitted with Weibull distribution.Conclusion:Emulsification-evaporation technique could be used to prepare the solid lipid nanoparticles.

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What this paper is about

Objective:To prepare the solid lipid nanoparticles(SLN)by emulsification-evaporation technique,and to investigate the drug loading capacity of SLN.Methods:The influences of formulation and processing variables on the preparation and the quality of SLN were studied.The SLN containing Ketoprofen(KT-SLN)was prepared.The entrapment efficacy and drug release from SLN were assessed.Results:The mean size was(228.2±18.1)nm with polydispersity index of(0.217±0.022)and the zeta potential was-(21.4±0.6)mV.The best entrapment efficiency of KT-SLN was found to be(64.1±3.3)% and the release profile in vitro was best fitted with Weibull distribution.Conclusion:Emulsification-evaporation technique could be used to prepare the solid lipid nanoparticles.

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Available abstract

Objective:To prepare the solid lipid nanoparticles(SLN)by emulsification-evaporation technique,and to investigate the drug loading capacity of SLN.Methods:The influences of formulation and processing variables on the preparation and the quality of SLN were studied.The SLN containing Ketoprofen(KT-SLN)was prepared.The entrapment efficacy and drug release from SLN were assessed.Results:The mean size was(228.2±18.1)nm with polydispersity index of(0.217±0.022)and the zeta potential was-(21.4±0.6)mV.The best entrapment efficiency of KT-SLN was found to be(64.1±3.3)% and the release profile in vitro was best fitted with Weibull distribution.Conclusion:Emulsification-evaporation technique could be used to prepare the solid lipid nanoparticles.

Key concepts: Solid lipid nanoparticle, Zeta potential, Dispersity, Chromatography, Particle size, Nanoparticle, Evaporation, Chemistry

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