Outcomes of Two Ovulation Induction Protocols for Polycystic Ovary Syndrome patients Undergoing In Vitro Fertilization and Embryo Transfer: A Comparative Study

Objective To compare the treatment outcomes between gonadotropin-releasing hormone( GnRH)antagonist protocol and GnRH agonist long protocol applied to polycystic ovary syndrome( PCOS) patients undergoing in vitro fertilization and embryo transfer( IVF-ET). Methods One hundred and eighteen cases of PCOS patients undergoing IVF-ET were divided randomly into study groupcontrol group. Forty-eight patients in study group were subjected to a protocol of using GnRH antagonist. Seventy patients in control group were subjected to a long protocol of using GnRH agonist. The clinical outcomes of two groups were compared. Results There were no significant differences in the average number of oocyte,the mature rate of oocytes,the fertilization rate,the cleavage rate,the rate of high-quality embryos,the implantation rate,the pregnancy rate and the concentration of IL-1β in follicular fluid between two groups( P 0. 05).The time and doses of administration of gonadotropins in the study group were obviously less than those in the control group( P 0.05).The incidence and cycle cancellation rate of ovarian hyperstimulation syndrome( OHSS) in the study group were significantly lower than those in the control group( P 0. 05). Conclusion The GnRH antagonist protocol could decrease the incidence,cycle cancellation rate of OHSS as well as reduce the time and doses of administration of gonadotropins.However,the number of oocyte,the fertilization rate,the cleavage rates,the rate of high-quality embryos,the pregnancy rate and the implantation rate are not affected.