Comparison between a GnRH antagonist and a GnRH agonist flare-up protocol on the outcome of patients who underwent in vitro fertilization

Objective:To compared with the effect of the protocol of gonadotropin releasing hormone antagonist and the flare-up protocol of gonadotropin releasing hormone agonist on the outcome of patients who underwent in vitro fertilization. Methods: Referred patients who subjected to IVF between August 2006 and August 2007 were divided into two group: the study group: 54 patients were subjected to a protocol of gonadotropin-releasing hormone antagonist. The control group:132 patients were subjected to a flare-up protocol of gonadotropin-releasing hormone agonist. To record the doses of gonadotrophins(HMG and/or rFSH),the during of administration,the thickness of endometrium and the profile of hormone level on the day of HCG administration,the number of retrieved oocyte,the ratio of fertilization,the ratio of cleavage,the ratio of the good quantity embryos,implantation rate of embryo,pregnancy rate and the incidence rate of OHSS. Results: The two groups were similar with respect to the doses of gonadotrophins (HMG and/or rFSH),the duration of administration,the number of oocyte retrieval,the ratio of fertilization,the ratio of cleavage,implantation rate of embryo and the pregnancy rate(P0.05). Significant differences were found regarding the profile of hormone by analyzing statistically. Conclusion: We demonstrated that GnRH antagonist administration in patients undergoing IVF with the profile of serum E2 was reduced significantly,which decreased the incidence of OHSS. But did not impact the development of follicle and alter the oocyte competence,the ratio of cleavage,implantation rate of embryo and the pregnancy rate.These result demonstrated that the administration of GnRH antagonist provided a new option for patients who undergoing IVF on controlled ovarian stimulation protocol.