The application of small doses Spironolactone combined with Metoprolol in chronic heart failure

Objective: To observe the clinical effects of using small doses Spironolactone combined with Metoprolol on the chronic heart failure.Methods: 64 chronic heart failure patients were collected and randomly divided into treatment group(34 cases) and control group(30 cases).The treatment group was given small doses of Spironolactone combined with Metoprolol,the control group was given routine therapy in chronic heart failure,the clinical curative effect of two groups were compared.Results: Clinical effective rates of improving chronic heart failure in treatment group and control group were 97.10% and 76.70%,there was significant difference between two groups(P0.05).The two groups were compared,the incidence of adverse reaction had no significant difference(P0.05).Conclusion: Small doses of Spironolactone combined with Metoprolol is effective in the treatment of chronic heart failure,and has no serious adverse reactions.