Clinical Study of Pantoprazole Combined with Granisetron on Prevention and Cure of Alimentary Toxicities Caused by Tumor Chemotherapy

Objective To investigate the curative and adverse effects of pantoprazole combined with granisetron for alimentary toxicities caused by tumor chemotherapy.Methods One hundred and twenty-five cases involved in intractable vomiting caused by tumor chemotherapy were divided into two groups at random on the second chemotherapy cycle. Sixty-four patients of pantoprazole group were treated with pantoprazole +granisetron+dexathasone ,and sixty-one ones of control group were treated with granisetron+dexathasone.Results Pantoprazole group was superior to control group in the prevention of appetite loss, nausea and vomiting with significant difference (P0.05).Side-effects such as headache, stomachache, constipation, acratia, blushing, insomnia were similar(P0.05).Conclusion Pantoprazole combined with granisetron is a good choice in prevention of alimentary toxicities caused by tumor chemotherapy and worth extending its clinical application.