2010•Chinese Journal of Hospital PharmacyRequires access

Clinical study of pantoprazole combined with tropisetron on prevention and cure of alimentary toxicities caused by tumor chemotherapy

Jun Gao

Abstract

OBJECTIVE To investigate the curative effect of pantoprazole combined with tropisetron for alimentary toxicities caused by tumor chemotherapy.METHODS Ninety-six cases involved in intractabe vomiting caused by tumor chemotherapy were divided into two groups at random on the second chemotherapy cycle.Fifty patients of pantoprazole group were treated with pantroprazole + tropisetron +dexathasone,and forty-six patients of control group were treated with tropisetron+dexathasone.RESULTS Pantoprazole group was superior to control group in the prevention of appetite loss,nausea and vomiting with significant difference(P0.05).CONCLUSION Pantoprazole combined with tropisetron is a good choice in prevention of alimentary toxicities caused by tumor chemotherapy and worth extending its clinical application.

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Key concepts: Tropisetron, Pantoprazole, Chemotherapy, Medicine, Vomiting, Nausea, Gastroenterology, Chemotherapy-induced nausea and vomiting