CT perfusion imaging in preoperative grading of gliomas

Objective To detect the role and value of CT perfusion imaging in preoperative grading gliomas. Methods Twenty-five glioma patients (11 low grade astrocytomas and 14 high grade astrocytomas) underwent CT cerebral perfusion examination before operation. The patients' raw data were transferred to workstation and processed to analyze the CBF, CBV and PS maps. The absolute value and relative value of CBF, CBV and PS were measured in the parenchyma part of glioma and were processed statistically. Results The values of CBF, CBV and PS in glioma were all higher than those of the normal cerebral tissue. In the lesion area of low grade astrocytoma: rCBF 1.41±0.16,rCBV 2.31±0.28, rPS 6.67±2.88. In the lesion area of high grade astrocytoma: rCBF 4.96±2.17, rCBV 4.69±1.98, rPS 19.19±9.19. The significant differences of P value were noted as follows: CBV (P0.05), CBF and PS (P0.01). There were positive correlations among the CBV, CBF and PS value of tumor area, and the r value was 0.822, 0.753, and 0.657, respectively (P≤0.001). Conclusion CT perfusion imaging is valuable in preoperative grading gliomas in clinical procedures.