Diagnostic value of the combined detection of serum AFP, CEA, CA-199 and CA-50 in malignant tumors in digestive tract

Objective To investigate the value of combined detection of serum alpha fetoprotein (AFP), carcinoembryonic antigen (CEA), carbohydrate antigen 199 (CA-199) and carbohydrate antigen 50 (CA-50) in the diagnosis of malignant tumors in digestive tract. Methods 216 patients with malignant tumors in digestive tract were selected as group A, 50 patients with benign tumors in digestive tract were selected as group B, and 50 healthy individuals were selected as group C. The levels of four tumor markers (AFP, CEA, CA-199 and CA-50) were detected and compared between the three groups. Results AFP was mainly sensitive to liver cancer, with the detection rate of 57.1%. CEA was mainly sensitive to colorectal cancer and the detection rate was 40.7%. CA-199 was mainly sensitive to pancreatic carcinoma and the detection rate was 67.9%. CA-50 was generally sensitive to malignant tumors in digestive tract. The sensitivity of combined detection of tumor markers was higher. The detection rate showed statistically significant difference between group A, group B and group C (P0.05). Conclusion Combined detection of serum AFP, CEA, CA-199 and CA-50 could effectively improve the detection rate, and reduce the rate of missed diagnosis, which has great significance in the early diagnosis and prevention of malignant tumors in digestive tract.