Comparative Study on the Treatments for Hand- foot-mouth Disease in Children with Human Recombinant Interferon alph-1b and Ribavirin Respectively

Objective:To discuss the effect and safety of the treatment for children's hand- foot-mouth disease with human recombinantinterferon alph-1b. Methods:388 cases of children with hand-foot-mouth disease were randomly divided into two groups which were given the same support and symptomatic treatment. Treatment group,184 cases were treated with human recombinant interferon alph-1b, 1,1 ug(kg·d),intramuscular,2~10 10 ug/d muscle injection,1 times a day. The control group, 204 cases were treated with ribavirin〔10~15 mg /(kg·d)〕an intravenous drip. Results:The treatment group was better than control group(P 0.01) in the defervescence time,hand,foot and skin rash and mouth ulcer healing. In addition to that the individual children have a fever;there was no obvious side effect in the treatment group. Conclusion:Interferon treatment of hand,foot and mouth disease in children is safe and effective,and is worth popularizing clinically used.