The clinical efficiency and safety of perindopril indapamide in elderly patients with mild to moderate essential hypertension

Objective: To investigate the efficacy and safety of perindopril/indapamide(Biprel) elderly patients with mild to moderate essential hypertension.Methods: 129 elderly patients with mild to moderate essential hypertension were divided randomly into group Biprel and group felodipine.Sitting blood pressure was measured by the every 1～2 weeks,after 8 weeks,clinic systolic and diastolic blood pressure measurements and ambulatory blood pressure monitoring(ABPM) were performed at the end of placebo run-in period and at 8 weeks.Fasting blood glucose,blood lipid,blood creatinine,uric acid,blood potassium、blood natrium and blood chlorine were examined before and after 8 weeks treatment.Results: Comparing with before treatment,clinic systolic and diastolic blood pressure,the 24-hour mean,daytime and nocturnal blood pressure in both groups decreased significantly,but not difference between two groups.The trough : peak ratio for SBP and DBP were 81.5% and 83.4% with Biprel and 65.9% and 77.6% with felodipine.The smoothness index(SI) for SBP and DBP were 4.52and 4.83 with Biprel and 4.17and 4.47 with felodipine.The levels of blood glucose,blood lipid,blood creatinine,uric acid,blood potassium didn't change after treatment in two groups.Conclusion: Biprel can effectively reduce the 24hours blood pressure in elderly patients with mild to moderate essential hypertension.