Effect of Peri-Esophagogastric Devascularization with Splenectomy on Portal Venous Haemorheology in Patients with Portal Hypertension

Objective To investigate the effect of peri-esophagogastric devascularization with splenectomyon on the portal venous haemorheology in patients with portal hypertension and the relationships between the changes of preoperative portal venous haemorheology and postoperative portal venous haemorheology and the formation of portal vein thrombus.Methods A total of 49 patients with portal hypertension were operated with peri-esophagogastric devascularization with splenectomy(short for EGDS).The data of the preoperative portal venous haemorheology and postoperative portal venous haemorheology were analyzed.The patients were divided into portal vein thrombosis(PVT) group and group without portal vein thrombosis depended on whether they had PVT.The changes between the two groups of the preoperative portal venous haemorheology and postoperative portal venous haemorheology were compared.Results ①The markers related portal venous haemorheology of the 49 patients such as high shear rate of low shear rate of whole blood viscosity,plasma viscosity,relative low shear rate of whole blood viscosity,the contents of D-dimer,PLT and so on were increased by some degrees and the difference were significant(P0.05).The ones with higher level were easier to have PVT.②There were 15 patients with PVT and the incidence rate was 30.61%.The advancement degree of many portal venous haemorheology markers of PVT group were higher than the group without PVT and the differences were significant(P0.05 or).Conclusion The Peri-esophagogastric devascularization with splenectomy had significant effect on the portal venous haemorheology of the portal hypertension patients and the main manifest are the increasing of low shear rate of whole blood viscosity,plasma viscosity,the contents of D-dimer and PLT.Meanwhile,the portal hypertension patients with postoperative higher advancement level of these haemorheology markers has more risk to have PVT.